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KMID : 0377619710210040327
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Korean Jungang Medical Journal
1971 Volume.21 No. 4 p.327 ~ p.332
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Effects of Analeptics on Maze Learning in Mice
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Abstract
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In order to assess the effects of analeptics on learning, mice were tested in a single-T water maze after one of the following drug treatments: physiological saline; 0.33mg/kg of strychnine; 1mg/kg of d-amphetamine; 30mg/kg of caffeine.
The test chamber was a galvanized steel T-tank 11. 5cm wide and 18cm deep described by Latz´ et al. (1967). The maze was filled with 2224°C water to a depth of 10cm.
Drugs were administrated intraperitoneally 20-30min before testing. A session consisted of 3 information and 30 test trials. Correct trials and swimming time were served as an index of learning performance.
The results obtained were as follows:
1) As compared to physiological saline, acquisition was significantly improved after treatments of strychnine, d-amphetamine and caffeine (Table 1 & Fig. 1).
2) Swimming speed was not significantly differed from control but tended to shorten in strychnine(Table 2).
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